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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Sildenafil for Erectile Dysfunction (ED) is a treatment that contains 50mg of sildenafil as the active ingredient. The 'Viagra for Erectile Dysfunction Treatment' patent medicine is only available with a UK prescription. Sildenafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

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Health authorities have warned that nearly two thirds of elderly people suffer from depression, some with it.

A new study has shown that the medication Zoloft has caused troubling changes in patients' mood, sleep patterns, and relationships.

The study, from the European Medicines Evaluation Agency, found that patients who took Zoloft had a worsening of their depressive mood as measured by the Centre for Clinical Research EvaluatingDepression (CCRE).

The depressed patients taking Zoloft had an average dose increase of 7.6 times (about 5.1 times) of the dose a year before.

The change was more pronounced in the patients who also took Zoloft in a dose-dependent manner.

The researchers said the results suggest that Zoloft might have had an impact on patients' overall life. They found that patients who took Zoloft during the treatment period suffered from symptoms of depression including, but not limited to, impulsive, depressed, and sad mood.

The study's authors said the findings are "particularly concerning as they highlight the need to carefully weigh the risks associated with Zoloft and its therapeutic benefits in order to achieve the most effective treatment for depression".

The study was conducted by Dr Mark L. Dolin, director of the Institute for Clinical Evaluations and Research in London.

The study was presented at the Annual Meeting of the European Medicines Evaluation Agency in Barcelona.

"We were concerned that the findings would suggest that the antidepressant Zoloft may have had a serious impact on patients," he said. "Zoloft was originally developed as a medication to treat depression in older adults, but has since been approved to treat this condition in a much younger age group."

He also said that the findings were particularly concerning as they highlight the need to carefully weigh the risks associated with Zoloft and its therapeutic benefits in order to achieve the most effective treatment for depression.

The researchers said that the use of Zoloft during the treatment period might have been associated with a worsening of depressive symptoms as measured by the CCRE. This worsening could result in suicidal thoughts or behavior.

"The fact that Zoloft has been shown to cause suicidal thoughts and behaviour is also very worrying. These effects have been known to occur at a much higher rate in older people," said Dr Dolin.

The study authors said that while the findings were reassuring, it was important to consider the potential benefits on the elderly patients who take Zoloft for other reasons.

The researchers recommended that patients consider the benefits on the elderly who take Zoloft during treatment and report any changes in their mood, sleep patterns, and relationships.

They also recommended that Zoloft should not be used by people who have previously suffered depression.

The study was funded by Pfizer Inc, the makers of Viagra, Merck & Co, Merck & Co, Bristol-Myers Squibb Co, AstraZeneca PLC, Novartis AG, Pfizer, and Pfizer Inc.

Pfizer Inc is a major pharmaceutical company with a long history of developing and marketing medicines. Its medicines are used by millions of people around the world and are marketed by major pharmaceutical companies, including GlaxoSmithKline, Pfizer Inc, Pfizer USA, Novartis AG, Pfizer Canada, Teva Pharmaceuticals Ltd, Sandoz, and Sandoz Europe.

Zoloft is a prescription medication used to treat depression in people over the age of 18. It is also used to treat sexual problems and impotence in women.

The company also produces the generic version of Viagra and Cialis and other similar medicines.

The study was funded by Pfizer Inc, the makers of Viagra and Cialis and other similar medicines.

© 2023 KPMG Pharmaceuticals Ltd. All rights reserved.

Citation: Zoloft causes serious problems in elderly people (2023, August 2023) retrieved 26 May 2025 from https://medicalxpress.com/news/2023-08-depression.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Pendly P. D., Professor at the University of Surrey, University Hospital and Research Centre, London, UK, Director of the Institute for Clinical Evaluations and Research in London, UK. Director of the Institute for Clinical Evaluations and Research in London, UK.

What is Viagra?

Viagra, or the medicineadiesviagra, is used to treat erectile dysfunction in men.

Erectile dysfunction is a common condition affecting men of all ages. The condition can be related to physical inactivity or age.

There are 2 types of erectile dysfunction:

  • Erectile dysfunction from diabetes and cardiovascular conditions

How does Viagra work?

Viagra works by increasing blood flow to the penis during sexual stimulation.

How should I take Viagra?

Take one tablet about 30 minutes before you plan to have sex.

Your doctor may recommend taking one tablet before sex if you have diabetes.

Some common things to know about taking Viagra include:

  • You should not take more than one tablet a day
  • Taking Viagra with high blood pressure (hypertension) or cholesterol
  • It can be taken with or without food

Viagra side effects

Like all medicines, Viagra can cause side effects, although not everyone gets them.

The most common side effects are:

  • Headache
  • Flushing
  • Upset stomach
  • Blurred vision
  • Indigestion
  • Nasal congestion

What if I miss a dose of Viagra?

You could miss a dose of Viagra if you take too much of it.

Just take it as prescribed and it will help you get the best results.

You can take it up to 4 hours before sex. You can take Viagra with or without food. Do not take a double dose to make up for a missed dose.

If you take too much of Viagra, you may experience heart problems such as chest pain or fainting, even if you are not experiencing it at the moment.

It is important to remember that you are not to take more than your prescribed dose of Viagra, and that you must continue to take it even if you feel better.

Can I take Viagra with other medicines?

If you are on any other medicines, including any herbal medicines, medicines you take, or recreational drugs, you should not take Viagra. Taking Viagra with other medicines containing sildenafil, tadalafil, or vardenafil is not recommended.

If you have any underlying health conditions such as heart problems or high blood pressure, you should speak with a healthcare professional.

Taking Viagra with medicines such as:

  • Nitrates
  • Alpha-blockers
  • Riociguat
  • Other blood pressure medications

It is important to talk to your doctor about your use of Viagra before you start taking any new medicines, including herbal medicines.

What are the side effects of Viagra?

Some of the side effects of Viagra may include:

  • Dizziness

While side effects can be serious, they are not usually the reason you experience the most problems.

There are different reasons why you may experience side effects of Viagra.

Common side effects

Headache, flushing, or a stuffy or runny nose can be a common side effect of Viagra. These side effects usually go away when you stop taking Viagra.

Some common side effects of Viagra may include:

  • Back pain
  • Fainting
  • Heartburn

These side effects are usually not serious and go away on their own after you stop taking Viagra.

Viagra, or sildenafil citrate, is a medication used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis, helping to achieve and maintain an erection when sexually stimulated. It works by helping to relax the blood vessels in the penis, which allows for increased blood flow when sexually stimulated. It is available in various forms, including tablets, orally disintegrating wafers, and topical creams. Viagra is a prescription medication, and some people may experience side effects from it, including headache, dizziness, and flushing. It can cause side effects, including headache, flushing, nasal congestion, and indigestion. It's important to note that Viagra is only approved for people over the age of 18, and its safety and effectiveness have not been proven. It's also important to consult a healthcare professional before using Viagra or any other medication, especially if you have any underlying health conditions, especially if you take other medications.

Viagra, or sildenafil citrate, is a prescription medication used to treat erectile dysfunction (ED). It is available in various forms, including tablets, oral disintegrating wafers, and topical creams. Viagra is only approved for people over the age of 18, and its safety and effectiveness have not been proven.Viagra is a prescription medication, and some people may experience side effects from it, including headache, flushing, and indigestion. It's important to consult a healthcare professional before using Viagra or any other medication, especially if you have any underlying health conditions, especially if you take other medications.